★★★★★ 4.5 (2,633 Reviews)

Digestive Enzymes

Digestive Enzymes

A fast-acting 3-in-1 blend of 16 enzymes, 3 probiotic strains and prebiotic fiber, built to break down food, beat the bloat, and make every meal a happy one.‡

🫃Supports digestive health‡

🎈Helps reduce bloating‡

🥄Promotes nutrient absorption‡

🌿Supports gut function‡

  • files/045_e00d3f814445cac2e484b3e8c314a4e2908985ddfef61bd9a68cf7f2e96c8df3.jpg

    At first I was scared it would give me diarrhea, but not at all. Actually, I can go to the bathroom way more regularly now and I don’t feel bloated all day anymore. My stomach looks so much flatter, honestly this is exactly what I needed.

    Monica
  • files/050_29cf6ede682d05f0e5c9b7b5e709a7c9b961e90b77d04a81ea01b42e4dab01c2.jpg

    I always thought my stomach issues were just because of what I was eating. My stomach would be bloated almost every night even when I ate normally. Since I started taking these, my digestion has been way more regular and I just feel lighter after meals. I only wish I had tried them sooner.

    sarah
  • files/044_e2d08b16e626dbd8f3dad2af39dd539b4140623458917d242f8df13907eb0013.jpg

    I was really skeptical because I’ve already tried so many things for my bloating and nothing ever really worked. I’ve been taking this for a few weeks now and I can definitely tell the difference. I feel way less heavy after eating and I don’t have to unbutton my jeans at the end of the day anymore 😂

    Sandra

    Anyone who feels weighed down after meals — bloating, gas, sluggishness or general discomfort. It's especially helpful if you often feel heavy after eating, struggle with rich or protein-heavy meals, follow a plant-based, keto or high-fiber diet, or have noticed digestion slowing with age. Not for children under 18, or anyone pregnant, nursing or on prescription medication without speaking to a provider first.

    Your body makes its own enzymes to break food down — proteases for protein, lipases for fat, amylases for carbs. Aging, stress, processed diets and food sensitivities can leave that production short of what your meals demand. When enzyme activity falls behind, food sits in the gut longer than it should, and that is when the bloating and fullness show up. This formula pairs 16 targeted enzymes with prebiotic fiber, probiotic strains, and organic peppermint and ginger to soothe the stomach.

    Helps reduce occasional bloating so you feel lighter after meals. Eases post-meal discomfort and that heavy, sluggish feeling. Supports better digestion of proteins, fats and carbohydrates. Improves nutrient absorption. Nourishes a healthy gut microbiome with prebiotic fibers and probiotic strains. Soothes the stomach with organic peppermint and ginger.‡

    Made in the USA in a cGMP-certified facility. Third-party tested for purity and potency. Non-GMO. Vegan and vegetarian-friendly capsules. Gluten-free, dairy-free, soy-free. No artificial fillers, binders or preservatives.

    Take 1 capsule with your largest meal of the day, or as directed by your healthcare provider. For best results, take consistently — most people start noticing a difference within the first week. Store in a cool, dry place away from direct sunlight.‡

    Serving size 1 capsule. Prebiotic and probiotic blend 159mg: organic inulin (Jerusalem artichoke), organic acacia fiber, inulin (chicory), Bacillus subtilis BS50®, Bacillus coagulant, Bacillus clausii. Herbal blend 150mg: organic peppermint leaf, organic ginger root. Digestive enzyme blend 85mg: bromelain, amylase, protease 4.5, glucoamylase, protease 6.0, papain, lactase, protease 3.0, peptidase, cellulase, beta-glucanase, alpha-galactosidase, lipase, xylanase, hemicellulase, invertase.

    View full details
    RECOMMENDED BY SPECIALISTS

    Trust your gut to the experts

    Gastroenterologists, naturopaths and nutritionists
    review the evidence behind every formula
    we make.
    8 PHYSICIANS, NDS & PHDS
    8 SPECIALTIES, GASTRO TO OB/GYN
    100% OF FORMULAS REVIEWED
    Anders Dahlstrom MD, PHD
    IN THEIR WORDS 1 / 8
    “Children's guts aren't just small adult guts — every kids formula has to earn its place in the evidence.”

    Anders Dahlstrom

    Dr. Anders Dahlstrom, MD, PhD — Pediatric gastroenterology

    Jennifer Roelands MD
    IN THEIR WORDS 2 / 8
    “Women deserve formulas built on real clinical research — not marketing claims dressed up as science.”

    Jennifer Roelands

    Dr. Jennifer Roelands, MD — OB/GYN · Integrative medicine

    Mona Fahoum ND
    IN THEIR WORDS 3 / 8
    “I only put my name on a formula I'd give my own patients.”

    Mona Fahoum

    Dr. Mona Fahoum, ND — Naturopathic medicine

    Thiago Cavalcante MD, ND
    IN THEIR WORDS 4 / 8
    “If the research doesn't support the ingredient, it doesn't make it onto the label. Full stop.”

    Thiago Cavalcante

    Dr. Thiago Cavalcante, MD, ND — ENT · Naturopathic medicine

    Eric Wood ND
    IN THEIR WORDS 5 / 8
    “A supplement should do one thing exceptionally well. The dose is what separates real from theatrics.”

    Eric Wood

    Dr. Eric Wood, ND — Naturopathic medicine

    Angela Pifer FMN, LN, CN
    IN THEIR WORDS 6 / 8
    “Timing and dosing are where most supplements fall short — that's exactly where we start.”

    Angela Pifer

    Angela Pifer, FMN, LN, CN — Functional medicine nutrition

    Jerry Martel MD, MPH
    IN THEIR WORDS 7 / 8
    “Most of what I see in clinic starts with digestion. Get that right and everything downstream gets easier.”

    Jerry Martel

    Dr. Jerry Martel, MD, MPH — Gastroenterology

    Reagan Major DO
    IN THEIR WORDS 8 / 8
    “The gut and the brain are in constant conversation. We formulate with both ends of it in mind.”

    Reagan Major

    Dr. Reagan Major, DO — Psychiatry

    How it works once you start

    The enzymes work at your very first meal. The gut side lands between day 5 and day 14.

    1
    Day 1
    FIRST MEAL

    Enzymes meet your first meal

    16 enzymes go to work in the stomach, where the digestion actually starts — breaking down protein, fat, dairy, starch and fibrous veg before any of it can sit heavy or ferment into gas.‡

    2
    Days 2–4
    RESULTS BEGIN

    Meals stop sitting heavy

    Less post-meal bloating and heaviness as food gets broken down instead of lingering. Organic peppermint and ginger settle the stomach while the enzymes do the work.‡

    3
    Days 5–14
    RESULTS

    The gut side catches up

    3 Bacillus spore strains survive stomach acid on their own and settle in, with 150mg of prebiotic fiber feeding them. Digestion starts feeling smoother between meals, not just after them.‡

    4
    Week 3+
    NEW BASELINE

    Eat what you like again

    Enzymes handling each meal, probiotics and prebiotics holding the balance between them. The foods you'd started avoiding stop being a decision.‡

    One capsule with your biggest meal. That's the whole routine.

    — As featured in

    Serenia's Choice Digestive Enzymes make every meal easier on your gut, and the difference can be felt from the very first bite. Join thousands of happy customers who've made mealtime bloat a thing of the past.

    Why choose Physician's Choice Digestive Enzymes

    🍕

    16 enzymes, 1 capsule

    A diverse blend tackles proteins, fats, dairy, carbs and veggies so no food is off the table.‡

    🍎

    Beat the mealtime bloat

    Eases post-meal discomfort, heaviness and gas so you can eat what you love without the regret.‡

    🌿

    3-in-1 gut support

    Enzymes, 3 probiotic strains and prebiotic fiber team up to support gut function and digestive wellness.‡

    🛡️

    Immune defense

    Most of your immune system lives in your gut. Keeping digestion balanced supports it every day.‡

    Real people. Real results.

    ★★★★★
    — Jean Bailey Robor ✓

    Good to aid in digestion. Sooo helpful.

    ★★★★★

    Sometimes when I eat certain foods I feel bloated. When using this product, I've noticed I feel more comfortable after eating a meal.

    — Marcus P. ✓

    No more heavy dinners

    ★★★★★

    I take one with dinner and the difference is night and day. No more sitting on the couch afterwards feeling like a rock. Worth every penny.

    — Tammy Hardenburg ✓

    Finally found something that works

    ★★★★★

    I've always had trouble with bloating and breaking down my food. I saw this all over TikTok and decided to order it, and I was not disappointed. I highly suggest these.

    — Christina Lazzaro ✓

    Sooo helpful.

    ★★★★★

    I'm in my mid-30's and I get bloated after I drink water… let alone eat anything. This has been a miracle to help me not look like a puffer fish like all time.

    —Yendi D. ✓

    Unbelievably fast results

    ★★★★★

    I've been so uncomfortable due to bloating for months. This product has offered significant relief; my tummy no longer looks nor feels pregnant. I have been taking it about 4 days and I already feel better. Thank you for this solution!

    Better digestion. Less discomfort. Every day.

    Mealtime discomfort starts when your body can't fully break down food. Physician's Choice Digestive Enzymes support the digestion of proteins, fats, dairy and carbs so you can feel lighter, more comfortable and better after every meal.‡

    Advanced digestive enzyme blend A diverse blend of 16 enzymes works in the stomach to help break down proteins, fats, dairy, carbs and veggies so no food is off the table.‡

    3-in-1 gut support system 3 Bacillus spore probiotic strains plus 150mg of prebiotic fiber, with organic peppermint and ginger to settle the stomach.‡

    check_circle Supports protein, carb & fat digestion‡

    check_circle Helps reduce bloating‡

    check_circle Non-GMO & third-party tested

    check_circle Doctor-developed formula◊

    Support your digestion with confidence

    60-day risk-free guarantee

    Enzymes that work
    as hard as you do.

    🧠

    Beat the bloat

    Feel lighter and more comfortable after meals without giving up the foods you love.‡

    🍽️

    Eat without the aftermath

    No more heavy, sluggish feeling after a big meal. Just dinner, the way it should be.‡

    Digestive enzyme capsule
    🥗

    Break down 5 food groups

    16 enzymes tackle proteins, fats, dairy, carbs and veggies so nothing's off the menu.‡

    💧

    Get more from every bite

    Supports better nutrient absorption, so the food you eat actually works for you.‡

    Beat the bloat today
    💧 60-day risk-free guarantee

    How to take Digestive Enzymes

    We've made it effortless to add Digestive Enzymes to your routine — no powders, no fuss, just one easy capsule.

    counter_1 Take 1 capsule with your meal. Before, during or after — whatever's easiest.‡

    counter_2 Pair with water. Easy to swallow, no aftertaste. No refrigeration needed.

    counter_3 Eat more? Take more. Add another capsule for bigger meals or trigger foods.‡

    26 cents a day vs. what mealtime discomfort actually costs you

    Here's the real math on chasing digestive relief one fix at a time.

    Physician's Choice Digestive Enzymes
    • About 26 cents a day on the 180-count
    • 16 enzymes in a single capsule
    • 3 spore strains that survive stomach acid
    • 150mg of prebiotic fiber, same capsule
    • Peppermint and ginger to settle things
    • Works at the meal, not hours later
    • Subscribe and save up to 25%
    • 60-day money-back guarantee
    Everything else you've tried
    • × A probiotic alone: the meal still sits there
    • × A single-enzyme pill: one food group only
    • × Refrigerated probiotics: $30+ a bottle
    • × Antacids: masking it, every single time
    • × Cutting out food after food after food
    • × A GI copay for "keep a food diary": $40
    • × Months of trial and error, nothing changes
    • × Still bloated after dinner
    Get Digestive Enzymes
    $ About a quarter a day to start enjoying meals again.
    OUR PRODUCT QUALITY

    We hold our digestive support to a higher standard

    HONEST ANSWERS

    Your questions, answered.

    A probiotic only adds beneficial bacteria. This pairs 3 shelf-stable probiotic strains with 16 digestive enzymes, prebiotic fibers to feed those bacteria, and organic peppermint and ginger. Think of it less as a probiotic and more as a complete digestive support system.
    Yes. It's designed for daily, ongoing use and is not habit-forming. Digestive enzymes don't reduce your body's natural enzyme production. Many customers take it daily for years.
    Yes. The serving is 1 capsule with your largest meal, but many people take an extra one with other heavy meals. Most don't exceed 2 a day. If you'd like to take more than that regularly, check with your healthcare provider.
    Speak with your healthcare provider first. They know your full health picture and can advise what's right for you.
    Because the enzymes are meant to start working in your stomach. A delayed-release shell would bypass the exact window where they do their best work. The probiotics are protected differently — spore-forming Bacillus strains are naturally acid-resistant.
    About 2 years from the date of manufacture — the exact date is printed on the bottom of your bottle. Store somewhere cool and dry; a kitchen cabinet beats the bathroom, where shower humidity can shorten shelf life.
    Yes, both. The capsule is plant-based hypromellose, the enzymes are microbial and plant-derived — bromelain from pineapple, papain from papaya — and every other ingredient is plant-sourced.
    Most people tolerate it well. Some notice mild changes in digestion during the first few days as their gut adjusts; this usually settles within a week. If you have a pineapple (bromelain) or papaya (papain) allergy, check the ingredients or speak with your provider first.

    Still deciding?

    Every order is covered for 60 days. Finish the bottle, and if your meals aren't sitting better, we'll refund you.

    Eat everything.

    Regret nothing.

    Bloating, heaviness and post-meal regret start when your body can't fully break down what you're eating. Physician's Choice Digestive Enzymes pack 16 enzymes, 3 probiotic strains and prebiotic fiber into one easy capsule so you can dig in without the aftermath.‡

    Make every meal better

    🔬Third-party tested

    🩺Developed with doctors◊

    🛡️60-day money-back guarantee